Article
Mutant-Allele Tumor Heterogeneity Scores Correlate With Risk of Metastases in Colon Cancer.
Clinical colorectal cancer - 1 Sept 2017
Rajput Ashwani, Bocklage Thèrése, Greenbaum Alissa, Lee Ji-Hyun, Ness Scott A
Abstract excerpt
BACKGROUND: Colorectal cancer is a leading cause of cancer-related mortality, has a very broad mutational spectrum, and there is no clinically available biomarker that can predict which patients with stage II or stage III colorectal cancer will develop metastatic disease. PATIENTS AND METHODS: We used a targeted next-generation sequencing approach to analyze the mutational spectra in stage II and III colon cancer...
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