Article
Clinical significance and prognostic relevance of KRAS, BRAF, PI3K and TP53 genetic mutation analysis for resectable and unresectable colorectal liver metastases: A systematic review of the current evidence.
Surgical oncology - 1 Jun 2018
Tsilimigras Diamantis I, Ntanasis-Stathopoulos Ioannis, Bagante Fabio, Moris Demetrios, Cloyd Jordan, Spartalis Eleftherios, Pawlik Timothy M
Abstract excerpt
BACKGROUND: Hepatic resection is considered the optimal potentially curative treatment for colorectal liver metastases (CRLM). Following resection, up to two-thirds of patients will develop recurrence within 5-years. Genetic mutation analysis of CRLM, especially KRAS status, has been proposed as a means to guide treatment, as well as identifying patients who can derive the most survival benefit from hepatic...
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