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Article

Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and Thrombosis.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2016

Delaney M Keegan, Kim Kyungho, Estevez Brian, Xu Zheng, Stojanovic-Terpo Aleksandra, Shen Bo, Ushio-Fukai Masuko, Cho Jaehyung, Du Xiaoping

Abstract excerpt

OBJECTIVE: Reactive oxygen species (ROS) are known to regulate platelet activation; however, the mechanisms of ROS production during platelet activation remain unclear. Platelets express different isoforms of nicotinamide adenine dinucleotide (phosphate) (NAD(P)H) oxidases (NOXs). Here, we investigated the role of NOX1 and NOX2 in ROS generation and platelet activation using NOX1 and NOX2 knockout mice. APPROACH...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26988594
DOI: 10.1161/ATVBAHA.116.307308
PMCID: PMC4850088

Genes

NOX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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