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Article

A novel role for thioredoxin-related transmembrane protein TMX4 in platelet activation and thrombus formation.

Journal of thrombosis and haemostasis : JTH - 1 Jan 2025

Zhao Zhenzhen, Wang Yucan, Yang Aizhen, Lu Yi, Yan Xiaofeng, Peng Meinan, Han Yue, Fang Chao, Wu Depei, Wu Yi

Abstract excerpt

BACKGROUND: The functions of critical platelet proteins are controlled by thiol-disulfide exchanges, which are mediated by the protein disulfide isomerase (PDI) family. It has been shown that some PDI family members are important in platelet activation and thrombosis with distinct functions. TMX4, a membrane-type PDI family member, is expressed in platelets, but whether it has a role in platelet activation...

Topics

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Chlorides
Ferric Compounds
Platelet Activation
Platelet Aggregation
Platelet Glycoprotein GPIIb-IIIa Complex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Disulfide-Isomerases

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Identifiers

PMID: 39307246
DOI: 10.1016/j.jtha.2024.09.007

Genes

TMX4
LAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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