Article
ALDH2 rs671 variant enhances platelet activation and thrombosis by disrupting mitochondrial complex I assembly.
Cardiovascular research - 22 Nov 2025
Zhong Haoxuan, Waresi Maieryemu, Qi Zhiyong, Zhou Luning, Zhang Wei, Sun Xiaolei, Han Liping, Chen Zhihan, Zhou Wenxuan, Zhang Peng, Xu Huajie, Zhang Si, Wu Hongyi, Sun Aijun, Ge Junbo
Abstract excerpt
AIMS: Aldehyde dehydrogenase 2 (ALDH2) is a critical mitochondrial enzyme responsible for aldehyde detoxification and maintenance of redox homeostasis. The rs671 variant, a prevalent loss-of-function mutation in East Asian populations (30-50% carrier frequency), diminishes ALDH2 enzymatic activity by 60-90% and is associated with elevated thrombotic risk. Although platelet activation is known to play a central...
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