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Article

Platelet-associated NAD(P)H oxidase contributes to the thrombogenic phenotype induced by hypercholesterolemia.

Free radical biology & medicine - 1 Jul 2007

Stokes Karen Y, Russell Janice M, Jennings Merilyn H, Alexander J Steven, Granger D Neil

Abstract excerpt

Elevated cholesterol levels promote proinflammatory and prothrombogenic responses in venules and impaired endothelium-dependent arteriolar dilation. Although NAD(P)H oxidase-derived superoxide has been implicated in the altered vascular responses to hypercholesterolemia, it remains unclear whether this oxidative pathway mediates the associated arteriolar dysfunction and platelet adhesion in venules. Platelet and...

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Identifiers

PMID: 17561090
DOI: 10.1016/j.freeradbiomed.2007.02.027
PMCID: PMC1975956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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