Article
Platelet-Specific p38α Deficiency Improved Cardiac Function After Myocardial Infarction in Mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2017
Shi Panlai, Zhang Lin, Zhang Mingliang, Yang Wenlong, Wang Kemin, Zhang Junfeng, Otsu Kinya, Huang Gonghua, Fan Xuemei, Liu Junling
Abstract excerpt
OBJECTIVE: MAPKs (mitogen-activated protein kinases), especially p38, play detrimental roles in cardiac diseases and cardiac remodeling post-myocardial infarction. However, the activation and function of MAPKs in coronary thrombosis in vivo and its relationship with clinical outcomes remain poorly understood. APPROACH AND RESULTS: Here, we showed that p38α was the major isoform expressed in human and mouse...
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