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Article

Hypoxia and Ischemia Promote a Maladaptive Platelet Phenotype.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2018

Cameron Scott J, Mix Doran S, Ture Sara K, Schmidt Rachel A, Mohan Amy, Pariser Daphne, Stoner Michael C, Shah Punit, Chen Lijun, Zhang Hui, Field David J, Modjeski Kristina L, Toth Sandra, Morrell Craig N

Abstract excerpt

OBJECTIVE: Reduced blood flow and tissue oxygen tension conditions result from thrombotic and vascular diseases such as myocardial infarction, stroke, and peripheral vascular disease. It is largely assumed that while platelet activation is increased by an acute vascular event, chronic vascular inflammation, and ischemia, the platelet activation pathways and responses are not themselves changed by the disease...

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Source

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Identifiers

PMID: 29724818
DOI: 10.1161/ATVBAHA.118.311186
PMCID: PMC6023774

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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