Transcriptome analysis of islets from diabetes‐resistant and diabetes‐prone obese mice reveals novel gene regulatory networks involved in beta‐cell compensation and failure

Abstract excerpt

The mechanisms underpinning beta-cell compensation for obesity-associated insulin resistance and beta-cell failure in type 2 diabetes remain poorly understood. We used a large-scale strategy to determine the time-dependent transcriptomic changes in islets of diabetes-prone db/db and diabetes-resistant ob/ob mice at 6 and 16 weeks of age. Differentially expressed genes were subjected to cluster, gene ontology,...

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