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The emerging role of FOXO transcription factors in pancreatic β cells

30 Apr 2007

Abstract excerpt

FOXO transcription factors critically control fundamental cellular processes, including metabolism, cell differentiation, cell cycle arrest, DNA repair, and other reactions to cellular stress. FOXO factors sense the balance between stimuli promoting growth and differentiation versus stress stimuli signaling damage. Integrated through the FOXO system, these divergent stimuli decide on cell fate, a choice between...

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PMID: 17470511
DOI: 10.1677/joe-06-0191

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