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Article

Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming

13 May 2022

Abstract excerpt

Pancreatic β cell plasticity is the primary determinant of disease progression and remission of type 2 diabetes (T2D). However, the dynamic nature of β cell adaptation remains elusive. Here, we establish a mouse model exhibiting the compensation-to-decompensation adaptation of β cell function in response to increasing duration of high-fat diet (HFD) feeding. Comprehensive islet functional and transcriptome...

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PMID: 35652891
DOI: 10.1084/jem.20211779

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