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Article

Analysis of Foxo1-regulated genes using Foxo1-deficient pancreatic β cells.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Sept 2012

Miyazaki Satsuki, Minamida Rie, Furuyama Tatsuo, Tashiro Fumi, Yamato Eiji, Inagaki Shinobu, Miyazaki Jun-ichi

Abstract excerpt

Several reports have suggested that Foxo1, a key regulator in differentiation, growth and metabolism, is involved in pancreatic β-cell function. However, detailed analyses have been hampered by a lack of Foxo1-deficient β cells. To elucidate Foxo1's function in β cells, we produced a β-cell line with inducible Foxo1 deletion. We generated a conditional knockout mouse line, in which Cre recombinase deletes the...

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Identifiers

PMID: 22845550
DOI: 10.1111/j.1365-2443.2012.01625.x

Genes

FOXO1

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Related research

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Analysis of Foxo1-regulated genes using Foxo1-deficient pancreatic β cells.PMID 22845550Read ↗

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