Article
A mutant allele encoding DNA binding-deficient FoxO1 differentially regulates hepatic glucose and lipid metabolism.
Diabetes - 1 Jun 2015
Cook Joshua R, Matsumoto Michihiro, Banks Alexander S, Kitamura Tadahiro, Tsuchiya Kyoichiro, Accili Domenico
Abstract excerpt
Insulin signaling in the liver blunts glucose production and stimulates triglyceride biosynthesis. FoxO1 is required for cAMP induction of hepatic glucose production and is permissive for the effect of insulin to suppress this process. Moreover, FoxO1 ablation increases lipogenesis. In this study, we investigated the pleiotropic actions of FoxO1 on glucose and lipid metabolism. To this end, we reconstituted FoxO1...
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