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A Review of FoxO1-Regulated Metabolic Diseases and Related Drug Discoveries

10 Jan 2020

Abstract excerpt

FoxO1 is a conserved transcription factor involved in energy metabolism. It is tightly regulated by modifications on its mRNA and protein and responds to environmental nutrient signals. FoxO1 controls the transcription of downstream genes mediating metabolic regulation. Dysfunction of FoxO1 pathways results in several metabolic diseases, including diabetes, obesity, non-alcoholic fatty liver disease, and...

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PMID: 31936903
DOI: 10.3390/cells9010184

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