Article
LSD1 modulates stress-evoked transcription of immediate early genes and emotional behavior.
Proceedings of the National Academy of Sciences of the United States of America - 29 Mar 2016
Rusconi Francesco, Grillo Barbara, Ponzoni Luisa, Bassani Silvia, Toffolo Emanuela, Paganini Leda, Mallei Alessandra, Braida Daniela, Passafaro Maria, Popoli Maurizio, Sala Mariaelvina, Battaglioli Elena
Abstract excerpt
Behavioral changes in response to stressful stimuli can be controlled via adaptive epigenetic changes in neuronal gene expression. Here we indicate a role for the transcriptional corepressor Lysine-Specific Demethylase 1 (LSD1) and its dominant-negative splicing isoform neuroLSD1, in the modulation of emotional behavior. In mouse hippocampus, we show that LSD1 and neuroLSD1 can interact with transcription factor...
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