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Article

Stress increases DNA methylation of the neuronal PAS domain 4 (Npas4) gene.

Neuroreport - 30 Sept 2015

Furukawa-Hibi Yoko, Nagai Taku, Yun Jaesuk, Yamada Kiyofumi

Abstract excerpt

Neuronal Per Arnt Sim domain 4 (Npas4), a brain-specific helix-loop-helix transcription factor, was recently shown to regulate the development of GABAergic inhibitory neurons. Npas4 mRNA expression levels were decreased in the hippocampus of mice exposed to stress, which was accompanied by brain dysfunction. We have suggested that transient stress reduced Npas4 transcription through the glucocorticoid receptor....

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Identifiers

PMID: 26222956
DOI: 10.1097/WNR.0000000000000430

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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