Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dynamic DNA methylation programs persistent adverse effects of early-life stress.

Nature neuroscience - 1 Dec 2009

Murgatroyd Chris, Patchev Alexandre V, Wu Yonghe, Micale Vincenzo, Bockmühl Yvonne, Fischer Dieter, Holsboer Florian, Wotjak Carsten T, Almeida Osborne F X, Spengler Dietmar

Abstract excerpt

Adverse early life events can induce long-lasting changes in physiology and behavior. We found that early-life stress (ELS) in mice caused enduring hypersecretion of corticosterone and alterations in passive stress coping and memory. This phenotype was accompanied by a persistent increase in arginine vasopressin (AVP) expression in neurons of the hypothalamic paraventricular nucleus and was reversed by an AVP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Newborn
Share to Arginine Vasopressin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Behavior, Animal

Share to Corticosterone

Share to Depression

Share to Enhancer Elements, Genetic

Share to Hypothalamo-Hypophyseal System

Share to Methyl-CpG-Binding Protein 2

Source

Identifiers

PMID: 19898468
DOI: 10.1038/nn.2436

Genes

AVP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dynamic DNA methylation programs persistent adverse effects of early-life stress.PMID 19898468Read ↗

Genes learn from stress: how infantile trauma programs us for depression.Semantic proximity Read ↗

Early-Life Stress Reduces DNA Methylation of the Pomc Gene in Male MiceSemantic proximity Read ↗

Role of Mecp2 in Experience-Dependent Epigenetic ProgrammingSemantic proximity Read ↗

Epigenetic regulation of brain development, plasticity, and response to early-life stressSemantic proximity Read ↗

Unraveling the epigenetic landscape of depression: focus on early life stress .Semantic proximity Read ↗

Perinatal stress and epigenetics.Semantic proximity Read ↗

Early-life adversity and long-term neurobehavioral outcomes: epigenome as a bridge?Semantic proximity Read ↗

The lasting impact of early-life adversity on individuals and their descendants: potential mechanisms and hope for intervention.Semantic proximity Read ↗

The genome- and system-wide response of DNA methylation to early life adversity and its implication on mental health.Semantic proximity Read ↗

Cell-type-specific epigenetic effects of early life stress on the brainSemantic proximity Read ↗

Epigenetic Programming Effects of Early Life Stress: A Dual-Activation HypothesisSemantic proximity Read ↗

Sensitive periods in epigenetics: bringing us closer to complex behavioral phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.