Article
PKCα-mediated phosphorylation of LSD1 is required for presynaptic plasticity and hippocampal learning and memory.
Scientific reports - 7 Jul 2017
Lim Chae-Seok, Nam Hye Jin, Lee Jaehyun, Kim Dongha, Choi Ja Eun, Kang SukJae Joshua, Kim Somi, Kim Hyopil, Kwak Chuljung, Shim Kyu-Won, Kim Siyong, Ko Hyoung-Gon, Lee Ro Un, Jang Eun-Hae, Yoo Juyoun, Shim Jaehoon, Islam Md Ariful, Lee Yong-Seok, Lee Jae-Hyung, Baek Sung Hee, Kaang Bong-Kiun
Abstract excerpt
Lysine-specific demethylase 1 (LSD1) is a histone demethylase that participates in transcriptional repression or activation. Recent studies reported that LSD1 is involved in learning and memory. Although LSD1 phosphorylation by PKCα was implicated in circadian rhythmicity, the importance of LSD1 phosphorylation in learning and memory is unknown. In this study, we examined the roles of LSD1 in synaptic plasticity...
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