HDAC1 links early life stress to schizophrenia-like phenotypes.

doi:10.1073/pnas.1613842114

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Article

HDAC1 links early life stress to schizophrenia-like phenotypes.

Proceedings of the National Academy of Sciences of the United States of America - 6 Jun 2017

Bahari-Javan Sanaz, Varbanov Hristo, Halder Rashi, Benito Eva, Kaurani Lalit, Burkhardt Susanne, Anderson-Schmidt Heike, Anghelescu Ion, Budde Monika, Stilling Roman M, Costa Joan, Medina Juan, Dietrich Detlef E, Figge Christian, Folkerts Here, Gade Katrin, Heilbronner Urs, Koller Manfred, Konrad Carsten, Nussbeck Sara Y, Scherk Harald, Spitzer Carsten, Stierl Sebastian, Stöckel Judith, Thiel Andreas, von Hagen Martin, Zimmermann Jörg, Zitzelsberger Antje, Schulz Sybille, Schmitt Andrea, Delalle Ivana, Falkai Peter, Schulze Thomas G, Dityatev Alexander, Sananbenesi Farahnaz, Fischer André

Abstract excerpt

Schizophrenia is a devastating disease that arises on the background of genetic predisposition and environmental risk factors, such as early life stress (ELS). In this study, we show that ELS-induced schizophrenia-like phenotypes in mice correlate with a widespread increase of histone-deacetylase 1 (Hdac1) expression that is linked to altered DNA methylation. Hdac1 overexpression in neurons of the medial...

Topics

Adult
Aged
Animals
DNA Methylation
Female
Hippocampus
Histone Deacetylase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Histone Deacetylase Inhibitors

Humans

Male

Mice

Mice, Inbred C57BL

Mice, Mutant Strains

Mice, Transgenic

Middle Aged

Phenotype

Prefrontal Cortex

RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 28533418
DOI: 10.1073/pnas.1613842114
PMCID: PMC5468618

Genes

HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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