Article
Dlk1 dosage regulates hippocampal neurogenesis and cognition.
Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 2021
Montalbán-Loro Raquel, Lassi Glenda, Lozano-Ureña Anna, Perez-Villalba Ana, Jiménez-Villalba Esteban, Charalambous Marika, Vallortigara Giorgio, Horner Alexa E, Saksida Lisa M, Bussey Timothy J, Trejo José Luis, Tucci Valter, Ferguson-Smith Anne C, Ferrón Sacri R
Abstract excerpt
Neurogenesis in the adult brain gives rise to functional neurons, which integrate into neuronal circuits and modulate neural plasticity. Sustained neurogenesis throughout life occurs in the subgranular zone (SGZ) of the dentate gyrus in the hippocampus and is hypothesized to be involved in behavioral/cognitive processes such as memory and in diseases. Genomic imprinting is of critical importance to brain...
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