Article

Essential roles of Hdac1 and 2 in lineage development and genome-wide DNA methylation during mouse preimplantation development

2019-06-06

Abstract excerpt

Epigenetic modifications, including DNA methylation and histone modifications, are reprogrammed considerably following fertilization during mammalian early embryonic development. Incomplete epigenetic reprogramming is a major factor leading to poor developmental outcome in embryos generated by assisted reproductive technologies, such as somatic cell nuclear transfer. However, the role of histone modifications in p...

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Literature Corpus work: 09ffb93a-22ee-518b-908c-3455877dc8cc
DOI: 10.1101/662767

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