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Article

Embryo manipulation via assisted reproductive technology and epigenetic asymmetry in mammalian early development.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 5 Jan 2013

Kohda Takashi, Ishino Fumitoshi

Abstract excerpt

The early stage of mammalian development from fertilization to implantation is a period when global and differential changes in the epigenetic landscape occur in paternally and maternally derived genomes, respectively. The sperm and egg DNA methylation profiles are very different from each other, and just after fertilization, only the paternally derived genome is subjected to genome-wide hydroxylation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23166403
DOI: 10.1098/rstb.2012.0353
PMCID: PMC3539368

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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