Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals

Abstract excerpt

Imprinting abnormalities pose a significant challenge in applications involving embryonic stem cells, induced pluripotent stem cells, and animal cloning, with no universal correction method owing to their complexity and stochastic nature. In this study, we targeted these defects at their source-embryos from same-sex parents-aiming to establish a stable, maintainable imprinting pattern de novo in mammalian cells....

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• Share to Epigenetics and DNA Methylation
• Share to Genetic Syndromes and Imprinting
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