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Article

Contribution of inflammasome genetics in Plasmodium vivax malaria.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jun 2016

Santos Marina L S, Reis Edione Cristina, Bricher Pamela N, Sousa Tais N, Brito Cristiana F A, Lacerda Marcus V G, Fontes Cor J F, Carvalho Luzia H, Pontillo Alessandra

Abstract excerpt

Recent reports showed that, in mice, symptomatic Plasmodium infection triggers NLRP3/NLRP12-dependent inflammasome formation and caspase-1 activation in monocytes. In humans, few works demonstrated that inflammasome is activated in malaria. As Plasmodiumvivax is a potent inducer of inflammatory response we hypothesised that inflammasome genetics might affect P. vivax malaria clinical presentation. For this...

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Topics

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammasomes

Share to Interleukin-18

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Share to Malaria, Vivax

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Source

Identifiers

PMID: 26946405
DOI: 10.1016/j.meegid.2016.02.038

Genes

NLRP1
NLRP3
AIM2
CARD8
MEFV
NLRP12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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