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Article

CLEC4C p.K210del variant causes impaired cell surface transport in plasmacytoid dendritic cells of amyotrophic lateral sclerosis.

Oncotarget - 3 May 2016

Lim Su Min, Kim Young-Eun, Choi Won Jun, Oh Ki-Wook, Noh Min-Young, Kwon Min-Soo, Nahm Minyeop, Kim Namshin, Ki Chang-Seok, Kim Seung Hyun

Abstract excerpt

The type II C-type lectin CLEC4C is a transmembrane protein selectively expressed on plasmacytoid dendritic cells (PDCs). Although its mechanism of action remains unclear, triggering of the extracellular C-terminal C-type carbohydrate recognition region of CLEC4C regulates the secretion of proinflammatory cytokines and type I IFNs in PDCs. Applying whole-exome sequencing in a patient with juvenile amyotrophic...

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Identifiers

PMID: 26943047
DOI: 10.18632/oncotarget.7886
PMCID: PMC5041881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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