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Article

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes.

Nature - 13 Mar 2008

Kim You-Me, Brinkmann Melanie M, Paquet Marie-Eve, Ploegh Hidde L

Abstract excerpt

Signalling by means of toll-like receptors (TLRs) is essential for the development of innate and adaptive immune responses. UNC93B1, essential for signalling of TLR3, TLR7 and TLR9 in both humans and mice, physically interacts with these TLRs in the endoplasmic reticulum (ER). Here we show that the function of the polytopic membrane protein UNC93B1 is to deliver the nucleotide-sensing receptors TLR7 and TLR9 from...

Read the complete abstract on PubMed

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Share to Dendritic Cells
Share to Endocytosis
Share to Endoplasmic Reticulum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ligands

Share to Lysosomes

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Share to Toll-Like Receptor 7

Share to Toll-Like Receptor 9

Source

Identifiers

PMID: 18305481
DOI: 10.1038/nature06726

Genes

TLR7
TLR9
TLR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes.PMID 18305481Read ↗

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Secretion of the human Toll-like receptor 3 ectodomain is affected by single nucleotide polymorphisms and regulated by Unc93b1.Semantic proximity Read ↗

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