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Article

Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells.

Proceedings of the National Academy of Sciences of the United States of America - 16 Nov 2010

Blasius Amanda L, Arnold Carrie N, Georgel Philippe, Rutschmann Sophie, Xia Yu, Lin Pei, Ross Charles, Li Xiaohong, Smart Nora G, Beutler Bruce

Abstract excerpt

Despite their low frequency, plasmacytoid dendritic cells (pDCs) produce most of the type I IFN that is detectable in the blood following viral infection. The endosomal Toll-like receptors (TLRs) TLR7 and TLR9 are required for pDCs, as well as other cell types, to sense viral nucleic acids, but t...

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Identifiers

PMID: 21045126
DOI: 10.1073/pnas.1014051107
PMCID: PMC2993408

Genes

TLR7
TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21045126-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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