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Article

Multiple sclerosis-associated CLEC16A controls HLA class II expression via late endosome biogenesis.

Brain : a journal of neurology - 1 Jun 2015

van Luijn Marvin M, Kreft Karim L, Jongsma Marlieke L, Mes Steven W, Wierenga-Wolf Annet F, van Meurs Marjan, Melief Marie-José, der Kant Rik van, Janssen Lennert, Janssen Hans, Tan Rusung, Priatel John J, Neefjes Jacques, Laman Jon D, Hintzen Rogier Q

Abstract excerpt

C-type lectins are key players in immune regulation by driving distinct functions of antigen-presenting cells. The C-type lectin CLEC16A gene is located at 16p13, a susceptibility locus for several autoimmune diseases, including multiple sclerosis. However, the function of this gene and its potential contribution to these diseases in humans are poorly understood. In this study, we found a strong upregulation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25823473
DOI: 10.1093/brain/awv080
PMCID: PMC4614123

Genes

RILP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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