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Article

Multiple evolutionarily conserved Di-leucine like motifs in the carboxyl terminus control the anterograde trafficking of NKCC2.

The Journal of biological chemistry - 14 Dec 2012

Zaarour Nancy, Demaretz Sylvie, Defontaine Nadia, Zhu Yingying, Laghmani Kamel

Abstract excerpt

Mutations in the apical Na-K-2Cl co-transporter, NKCC2, cause type I Bartter syndrome, a life-threatening kidney disease. Yet the mechanisms underlying the regulation of NKCC2 trafficking in renal cells are scarcely known. We previously showed that naturally occurring mutations depriving NKCC2 of its distal COOH-terminal tail and interfering with the (1081)LLV(1083) motif result in defects in the ER exit of the...

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PMID: 23105100
DOI: 10.1074/jbc.M112.399162
PMCID: PMC3522265

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