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Article

mCLCA4 ER processing and secretion requires luminal sorting motifs.

American journal of physiology. Cell physiology - 1 Jul 2008

Huan Chunlei, Greene Kai Su, Shui Bo, Spizz Gwendolyn, Sun Haitao, Doran Robert M, Fisher Patricia J, Roberson Mark S, Elble Randolph C, Kotlikoff Michael I

Abstract excerpt

Ca(+)-activated Cl(-) channel (CLCA) proteins are encoded by a family of highly related and clustered genes in mammals that are markedly upregulated in inflammation and have been shown to affect chloride transport. Here we describe the cellular processing and regulatory sequences underlying murine (m) CLCA4 proteins. The 125-kDa mCLCA4 gene product is cleaved to 90- and 40-kDa fragments, and the NH(2)- and...

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Identifiers

PMID: 18495813
DOI: 10.1152/ajpcell.00060.2008
PMCID: PMC2493559

Genes

CLCA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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