Article
A Statistical Approach for Testing Cross-Phenotype Effects of Rare Variants.
American journal of human genetics - 3 Mar 2016
Broadaway K Alaine, Cutler David J, Duncan Richard, Moore Jacob L, Ware Erin B, Jhun Min A, Bielak Lawrence F, Zhao Wei, Smith Jennifer A, Peyser Patricia A, Kardia Sharon L R, Ghosh Debashis, Epstein Michael P
Abstract excerpt
Increasing empirical evidence suggests that many genetic variants influence multiple distinct phenotypes. When cross-phenotype effects exist, multivariate association methods that consider pleiotropy are often more powerful than univariate methods that model each phenotype separately. Although several statistical approaches exist for testing cross-phenotype effects for common variants, there is a lack of similar...
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