Article
Testing cross-phenotype effects of rare variants in longitudinal studies of complex traits.
Genetic epidemiology - 1 Jun 2018
Rudra Pratyaydipta, Broadaway K Alaine, Ware Erin B, Jhun Min A, Bielak Lawrence F, Zhao Wei, Smith Jennifer A, Peyser Patricia A, Kardia Sharon L R, Epstein Michael P, Ghosh Debashis
Abstract excerpt
Many gene mapping studies of complex traits have identified genes or variants that influence multiple phenotypes. With the advent of next-generation sequencing technology, there has been substantial interest in identifying rare variants in genes that possess cross-phenotype effects. In the presence of such effects, modeling both the phenotypes and rare variants collectively using multivariate models can achieve...
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