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Article

A general approach to testing for pleiotropy with rare and common variants.

Genetic epidemiology - 1 Feb 2017

Lutz Sharon M, Fingerlin Tasha E, Hokanson John E, Lange Christoph

Abstract excerpt

Through genome-wide association studies, numerous genes have been shown to be associated with multiple phenotypes. To determine the overlap of genetic susceptibility of correlated phenotypes, one can apply multivariate regression or dimension reduction techniques, such as principal components analysis, and test for the association with the principal components of the phenotypes rather than the individual...

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Identifiers

PMID: 27900789
DOI: 10.1002/gepi.22011
PMCID: PMC5472207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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