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Article

Pleiotropy in complex traits: challenges and strategies.

Nature reviews. Genetics - 1 Jul 2013

Solovieff Nadia, Cotsapas Chris, Lee Phil H, Purcell Shaun M, Smoller Jordan W

Abstract excerpt

Genome-wide association studies have identified many variants that each affects multiple traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders, suggesting that pleiotropic effects on human complex traits may be widespread. However, systematic detection of such effects is challenging and requires new methodologies and frameworks for interpreting cross-phenotype results. In this...

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Identifiers

PMID: 23752797
DOI: 10.1038/nrg3461
PMCID: PMC4104202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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