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Article

Kernel-based gene-environment interaction tests for rare variants with multiple quantitative phenotypes.

PloS one - 1 Jan 2022

Jin Xiaoqin, Shi Gang

Abstract excerpt

Previous studies have suggested that gene-environment interactions (GEIs) between a common variant and an environmental factor can influence multiple correlated phenotypes simultaneously, that is, GEI pleiotropy, and that analyzing multiple phenotypes jointly is more powerful than analyzing phenotypes separately by using single-phenotype GEI tests. Methods to test the GEI for rare variants with multiple...

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Identifiers

PMID: 36223383
DOI: 10.1371/journal.pone.0275929
PMCID: PMC9555665

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