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Article

Identity-By-Descent Mapping Using Multi-Individual IBD With Genome-Wide Multiple Testing Adjustment.

Genetic epidemiology - 1 Sept 2025

Cai Ruoyi, Browning Sharon R

Abstract excerpt

We present an identity-by-descent mapping approach to test the association between genome-wide loci and complex traits. Our method evaluates whether levels of genetic similarities at specific genomic locations, captured by local relatedness matrices derived from multi-individual IBD sharing, are associated with phenotypic variation in complex traits. In addition, we propose an approach to adjust for multiple...

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Identifiers

PMID: 40719186
DOI: 10.1002/gepi.70015
PMCID: PMC12327188

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