Article
An atlas of genetic correlations across human diseases and traits.
Nature genetics - 1 Nov 2015
Bulik-Sullivan Brendan, Finucane Hilary K, Anttila Verneri, Gusev Alexander, Day Felix R, Loh Po-Ru, Duncan Laramie, Perry John R B, Patterson Nick, Robinson Elise B, Daly Mark J, Price Alkes L, Neale Benjamin M
Abstract excerpt
Identifying genetic correlations between complex traits and diseases can provide useful etiological insights and help prioritize likely causal relationships. The major challenges preventing estimation of genetic correlation from genome-wide association study (GWAS) data with current methods are the lack of availability of individual-level genotype data and widespread sample overlap among meta-analyses. We...
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