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Article

Developmental Origins for Kidney Disease Due to Shroom3 Deficiency

3 Mar 2016

Abstract excerpt

CKD is a significant health concern with an underlying genetic component. Multiple genome–wide association studies (GWASs) strongly associated CKD with the shroom family member 3 ( SHROOM3 ) gene, which encodes an actin-associated protein important in epithelial morphogenesis. However, the role of SHROOM3 in kidney development and function is virtually unknown. Studies in zebrafish and rat showed that alterations...

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PMID: 26940091
DOI: 10.1681/asn.2015060621

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