Article
Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity.
Genome research - 1 Jan 2015
Yeo Nan Cher, O'Meara Caitlin C, Bonomo Jason A, Veth Kerry N, Tomar Ritu, Flister Michael J, Drummond Iain A, Bowden Donald W, Freedman Barry I, Lazar Jozef, Link Brian A, Jacob Howard J
Abstract excerpt
Genome-wide association studies (GWAS) identify regions of the genome correlated with disease risk but are restricted in their ability to identify the underlying causative mechanism(s). Thus, GWAS are useful "roadmaps" that require functional analysis to establish the genetic and mechanistic structure of a particular locus. Unfortunately, direct functional testing in humans is limited, demonstrating the need for...
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