Swimming Upstream to Understand Congenital Anomalies of the Kidney and Urinary Tract: Zebrafish Models for Developmental Biology, Disease Mechanisms, and Functional Interpretation of Genetic Variation.

doi:10.3390/genes17080867

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Swimming Upstream to Understand Congenital Anomalies of the Kidney and Urinary Tract: Zebrafish Models for Developmental Biology, Disease Mechanisms, and Functional Interpretation of Genetic Variation.

Genes - 24 Jul 2026

Nurcombe Zachary W, Mougharbel Lina, Kitzler Thomas M

Abstract excerpt

Congenital anomalies of the kidney and urinary tract (CAKUT) are the leading cause of pediatric chronic kidney disease (CKD) and comprise a heterogeneous group of developmental disorders with a substantial genetic contribution. Advances in next-generation sequencing have facilitated the identification of numerous candidate genes and rare variants associated with CAKUT. However, establishing causality and defining...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42650060
DOI: 10.3390/genes17080867
PMCID: PMC13536465

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