Article

Spatial Multi-Omics Connect SHROOM3 and COL18A1 in Chronic Kidney Disease

2024-02-11

Abstract excerpt

Shroom Family Member 3 ( SHROOM3) encodes an actin-binding protein that impacts kidney development. Genome-wide association studies (GWAS) identified CKD-associated common variants around SHROOM3 and Shroom3 knock-out mice develop glomerular abnormalities. We sought to evaluate the impact of genetically predicted SHROOM3 expression on kidney traits and the circulating proteome, and validate findings in a mouse mod...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4af18f20-33cc-5d03-ac4d-07e685f0a161
DOI: 10.1101/2024.02.09.24301246

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial Multi-Omics Connect SHROOM3 and COL18A1 in Chronic Kidney DiseaseDOI 10.1101/2024.02.09.24301246Read

Developmental Origins for Kidney Disease Due to Shroom3 DeficiencySemantic proximity Read

Shroom3-Rock interaction and profibrotic function: Resolving mechanism of an intronic CKD risk alleleSemantic proximity Read

Sept8/SEPTIN8 involvement in cellular structure and kidney damage is identified by genetic mapping and a novel human tubule hypoxic modelSemantic proximity Read

Characterization of Coding/Noncoding Variants for SHROOM3 in Patients with CKD.Semantic proximity Read

Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction.Semantic proximity Read

Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity.Semantic proximity Read

SHROOM3, the gene associated with chronic kidney disease, affects the podocyte structure.Semantic proximity Read

Glomerular Elastic Modulus and Gene Expression Patterns Define Two Phases of Alport NephropathySemantic proximity Read

A novel multi-ancestry proteome-wide Mendelian randomization study implicates extracellular proteins, tubular cells, and fibroblasts in estimated glomerular filtration rate regulationSemantic proximity Read

Human Kidney Alternative Splicing Information Illuminates Cardiovascular-Kidney-Metabolic Syndrome RiskSemantic proximity Read

SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and FunctionSemantic proximity Read

A Comprehensive Map of mRNAs and Their Isoforms across All 14 Renal Tubule Segments of MouseSemantic proximity Read