Article
Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction.
Nature communications - 30 Dec 2025
Reghuvaran Anand, Kumar Ashwani, Lin Qisheng, Rajeevan Nallakandi, Banu Khadija, Sun Zeguo, Shi Hongmei, Barsotti Gabriel, Tanvir E M, Pell John, Perincheri Sudhir, Wei Chengguo, Bharathan Bhavya, Planoutene Marina, Eichmann Anne, Mas Valeria, Zhang Weijia, Cantley Lloyd G, Xu Leyuan, Das Bhaskar, He John Cijiang, Menon Madhav C
Abstract excerpt
Enhancer variants in Shroom3 associate with renal fibrosis (TIF), but with reduced albuminuria. Detailed mechanisms for these pleiotropic effects are unclear. Here, we focus on identifying the specific profibrotic Shroom3 motif and separating this from its anti-proteinuric function. Given the role for Rho-kinases (Rock) in TIF, and the interaction of Rock with Shroom3 ASD2-domain, we hypothesized that...
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