Intronic locus determines SHROOM3 expression and potentiates renal allograft fibrosis.

doi:10.1172/JCI76902

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Article

Intronic locus determines SHROOM3 expression and potentiates renal allograft fibrosis.

The Journal of clinical investigation - 1 Jan 2015

Menon Madhav C, Chuang Peter Y, Li Zhengzhe, Wei Chengguo, Zhang Weijia, Luan Yi, Yi Zhengzi, Xiong Huabao, Woytovich Christopher, Greene Ilana, Overbey Jessica, Rosales Ivy, Bagiella Emilia, Chen Rong, Ma Meng, Li Li, Ding Wei, Djamali Arjang, Saminego Millagros, O'Connell Philip J, Gallon Lorenzo, Colvin Robert, Schroppel Bernd, He John Cijiang, Murphy Barbara

Abstract excerpt

Fibrosis underlies the loss of renal function in patients with chronic kidney disease (CKD) and in kidney transplant recipients with chronic allograft nephropathy (CAN). Here, we studied the effect of an intronic SNP in SHROOM3, which has previously been linked to CKD, on the development of CAN in a prospective cohort of renal allograft recipients. The presence of the rs17319721 allele at the SHROOM3 locus in the...

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PMID: 25437874
DOI: 10.1172/JCI76902
PMCID: PMC4382250

Genes

SHROOM3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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