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Article

A human integrin-α3 mutation confers major renal developmental defects.

PloS one - 1 Jan 2014

Shukrun Rachel, Vivante Asaf, Pleniceanu Oren, Vax Einav, Anikster Yair, Dekel Benjamin, Lotan Danny

Abstract excerpt

The development of the mammalian kidney is a highly complex process dependent upon the interplay of various cell types, secreted morphogens, and the extra-cellular matrix (ECM). Although integrins are the most important receptors for ECM proteins and are ubiquitously expressed during kidney development, mice lacking expression of integrin α3 (Itga3) do not demonstrate a reduced number of nephrons, but mostly a...

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Source

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Identifiers

PMID: 24621570
DOI: 10.1371/journal.pone.0090879
PMCID: PMC3951280

Genes

ITGA3
PAX8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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