Article

Glomerular Elastic Modulus and Gene Expression Patterns Define Two Phases of Alport Nephropathy

2024-02-29

Abstract excerpt

Alport syndrome (AS), caused by COL4A3,4,5 mutations, leads to progressive glomerular disease and eventual kidney failure. In Col4α3 −/− mice (C57BL/6 background), we found that increased glomerular capillary deformability (reduced Young’s modulus, E) appears 2–3 months before detectable proteinuria or elevated serum creatinine. This early change indicates that podocyte injury precedes traditional clinical marker...

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Literature Corpus work: 16bee047-7b11-5372-af3b-6a001fb88b57
DOI: 10.1101/2024.02.26.582201

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