Article

Shroom3-Rock interaction and profibrotic function: Resolving mechanism of an intronic CKD risk allele

2024-11-23

Abstract excerpt

Common intronic enhancer SNPs in Shroom3 associate with CKD in GWAS, although there is paucity of detailed mechanism. Previously, we reported a role for Shroom3 in mediating crosstalk between TGFβ1- & Wnt/Ctnnb1 pathways promoting renal fibrosis (TIF). However, beneficial roles for Shroom3 in proteinuria have also been reported suggesting pleiotropic effects. Here we focused on identifying the specific profibrotic...

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Literature Corpus work: 9dd041bd-c6ef-5d5e-95bf-d4ac37184cdd
DOI: 10.1101/2024.11.22.624409

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