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Engineered human iPS cell models reveal altered podocytogenesis and glomerular capillary wall in CHD-associated <i>SMAD2</i> mutations

2024-08-06

Abstract excerpt

Early developmental programming involves extensive cell lineage diversification through shared molecular signaling networks. Clinical observations of congenital heart disease (CHD) patients carrying SMAD2 genetic variants revealed correlations with multi-organ impairments at the developmental and functional levels. For example, many CHD patients present with glomerulosclerosis, periglomerular fibrosis, and albumi...

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Literature Corpus work
3d225517-9e29-529d-893b-4f2be1d4528b
DOI
10.1101/2024.08.02.606108
Open publication

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Engineered human iPS cell models reveal altered podocytogenesis and glomerular capillary wall in CHD-associated <i>SMAD2</i> mutationsDOI 10.1101/2024.08.02.606108
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