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Article

Conditional targeted genome editing using somatically expressed TALENs in C. elegans.

Nature biotechnology - 1 Oct 2013

Cheng Ze, Yi Peishan, Wang Xiangming, Chai Yongping, Feng Guoxin, Yang Yihong, Liang Xing, Zhu Zhiwen, Li Wei, Ou Guangshuo

Abstract excerpt

We have developed a method for the generation of conditional knockouts in Caenorhabditis elegans by expressing transcription activator-like effector nucleases (TALENs) in somatic cells. Using germline transformation with plasmids encoding TALENs under the control of an inducible or tissue-specifi...

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PMID: 23955274
DOI: 10.1038/nbt.2674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23955274-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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