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Article

Systematic Evaluation of Drosophila CRISPR Tools Reveals Safe and Robust Alternatives to Autonomous Gene Drives in Basic Research.

G3 (Bethesda, Md.) - 20 May 2015

Port Fillip, Muschalik Nadine, Bullock Simon L

Abstract excerpt

The Clustered Regularly Interspaced Short Palindromic Repeat/CRISPR associated (CRISPR/Cas) technology allows rapid, site-specific genome modification in a wide variety of organisms . Proof-of-principle studies in Drosophila melanogaster have used various CRISPR/Cas tools and experimental designs, leading to significant uncertainty in the community about how to put this technology into practice. Moreover, it is...

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Identifiers

PMID: 25999583
DOI: 10.1534/g3.115.019083
PMCID: PMC4502383

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Source receipt: pubmed, retrieved 7 Sept 2026.

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