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Presynaptic Pathophysiology Encoded in Different Domains of Tau - Hyper-Versus Hypoexcitability?

Advances in experimental medicine and biology - 1 Jan 2019

Decker Jochen Martin, Mandelkow Eva-Maria

Abstract excerpt

Mutations in MAPT (Tau) have been implicated in several types of tauopathy, but the pathways leading to neurodegeneration have remained elusive and are heterogeneous. Here we describe the effects of two mutations, both linked to AD or FTD, that are located in different domains of Tau and show different pathways of toxicity. The deletion mutation ΔK280 lies in the repeat domain and strongly increases β-structure...

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PMID: 32096031
DOI: 10.1007/978-981-32-9358-8_8

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